Recent Publications
Mellor KM, Varma U, Koutsifeli P, Daniels LJ, Benson VL, Annandale M, Li X, Nursalim Y, Janssens JV, Weeks KL, Powell KL, O’Brien TJ, Katare R, Ritchie RH, Bell JR, Gottlieb RA, Delbridge LMD. Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy. Journal of Molecular & Cellular Cardiology 2024 In press.
Janssens JV, Raaijmakers AJA, Weeks KL, Bell JR, Mellor KM, Curl CL, Delbridge LMD. The cardiomyocyte origins of diastolic dysfunction: cellular components of myocardial “stiffness”. Am J Physiol Heart Circ Physiol. 2024 326(3):H584-H598.
Daniels LJ, Macindoe C, Koutsifeli P, Annandale M, James SL, Watson LE, Coffey S, Raaijmakers AJA, Weeks KL, Bell JR, Janssens JV, Curl CL, Delbridge LMD, Mellor KM. Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology. Scientific Reports 2023 13(1):12344.
Delbridge, L. M. D., Koutsifeli, P., Fong, S. P. T., Annandale, M., Weeks, K. L., Bell, J. R., & Mellor, K.M. Glycophagy – the physiological perspective on a newly characterized glycogen-selective autophagy. Current Opinion in Physiology 2022 30: 100598.
Delbridge, L.M.D, Bell, J.R., Weeks, K.L., Raaijmakers, A.J.A., Mellor, K.M. HFpEF etiology – can focus on sex-specific mechanisms deliver insights for all? Journal of Molecular & Cellular Cardiology 2022 173:71-72.
Janssens, J.V., Bell, J.R., Weeks, K.L., Mellor, K.M. Delbridge, L.M.D. The big picture: cardiac sex – age interactions and proteogenomic insights. American Journal of Physiology: Heart & Circulatory Physiology 2022 323(4):H640-H642.
Koutsifeli PK, Varma U, Daniels LJ, Annandale M, Li X, Neale JPH, Hayes S, James S, Delbridge LMD, Mellor, K.M. Glycogen-autophagy: molecular machinery and cellular mechanisms. Journal of Biological Chemistry 2022 298(7): 102093.
Heather LC, Hafstad AD, Halade GV, Harmancey R, Mellor, K.M., Mishra PK, Mulvihill EE, Nabben M, Nakamura M, Rider O, Ruiz M, Wende AR, Ussher JR. Guidelines on models of diabetic heart disease. J. Physiol. Heart Circ. Physiol. 2022 323(1): H176-200.
Han JC, Tran K, Crossman DJ, Curl CC, Koutsifeli P, Neale JPH, Harrap SB, Taberner AJ, Delbridge LMD, Loiselle DS, Mellor, K.M. Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function. Gen. Physiol. 2021 153(8):e202012841.
Annandale M, Daniels LJ, Li X, Neale J.P.H, Chau AHL, Ambalawanar HA, James SL, Koutsifeli P, Delbridge LMD, Mellor, K.M. Fructose metabolism and cardiac metabolic stress. Frontiers in Pharmacology 2021 12: 1538.
Daniels LJ, Annandale A, Koutsifeli P, Li X, Bussey CT, van Hout I, Bunton RW, Davis P, Coffey S, Katare R, Lamberts RR, Delbridge LMD, Mellor, K.M. Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro. Nutrition & Diabetes 2021 11(1):8.
Delbridge LMD, Ritchie RH, Mellor, K.M., Jenkins AJ. Heart failure: the heart afflicted by diabetes. Diabetes Management Journal 2020 Nov edn.
Daniels LJ, Varma U, Annandale M, Chan E, Mellor, K.M., Delbridge LMD. Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses. Antioxid Redox Signal. 2019 31:472-86.
Janssens JV, Ma B, Brimble MA, Van Eyk JE, Delbridge LMD, Mellor, K.M. Cardiac troponins may be irreversibly modified by glycation: novel potential mechanisms of cardiac performance modulation. Sci Rep, 2018 8:16084.
Chandramouli C, Reichelt ME, ….. Ritchie RH, Mellor, K.M., Delbridge LMD. Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia. Sci Rep. 2018 8(1) 2346.
Varma U, Koutsifeli P, Benson VL, Mellor, K.M.*, Delbridge LMD*. Molecular mechanisms of cardiac pathology in diabetes- Experimental insights. Biophys. Acta-Mol. Basis Dis. 2018 1864, 1949-1959.
Delbridge LM*, Mellor, K.M.*, Taylor DJ, Gottlieb RA. Myocardial stress and autophagy: mechanisms and interventional prospects. Nature Reviews Cardiology 2017 14(7):412-425.
Delbridge LM, Bienvenu LA, Mellor, K.M. Angiotensin-(1-9): New promise for post-infarct functional therapy. J Am Coll Cardiol. 2016 68(24):2667-2669.
Delbridge LM, Benson VL, Ritchie RH, Mellor, K.M. Diabetic cardiomyopathy: the case for a role of fructose in disease etiology. 2016 65:3521.